Breaking: Police pursuit ends in serious crash in Perth's south

The front of this car was ripped off in the crash, which happened on South Street in Leeming. (ABC News)

A person has been rushed to hospital and another is in custody after a police pursuit through Perth's southern suburbs ended in a serious crash.

The crash happened just before 11am, with fire and ambulance crews rushing to the scene on South Street in Leeming, near the intersection of Beasley Road.

St John Ambulance said a man was taken to Royal Perth Hospital under the highest priority, while a man in his 40s and a woman in her 30s were taken to Fiona Stanley Hospital.

Aerial vision from the scene shows the front of a white sedan had been ripped off before the car eventually came to a standstill in the westbound lanes of South St.

The car's engine was ejected in the smash, landing 50 metres away on the opposite side of the six-lane road.

Another black van 90 metres further down the road has a smashed windscreen and a metal road sign lodged in its bonnet.